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Meg Ryan has published a heartfelt tribute to the deceased filmmaker Rob Reiner, who was her director in the beloved romantic comedy When Harry Met Sally.

A Heartbreaking Event

Reiner was located lifeless with his wife, Michele Singer Reiner, at their Los Angeles home this past weekend.

“We will miss this man so deeply…” the actress posted on Instagram, accompanying a photo of them together. “Thank you, Rob and Michelle [sic], for the way you believe in true love, in fairy tales, and in laughter. We appreciate your faith in human goodness and your deep patriotism.”

Court Case Developments

Reiner’s son Nick, 32, has been charged with two counts of first-degree murder and made a court appearance today. He’s being held without bail. It’s been reported that Reiner’s daughter Romy discovered her father deceased.

“I have to believe that their story will not end with this impossible tragedy, that some good may come, some awareness raised,” Ryan continued. “While uncertain, I suspect they'd wish for a hopeful, compassionate outcome that fosters mutual understanding and peace.”

A Statement from Siblings

Reiner’s other children Jake and Romy released a message today. “Words cannot even begin to describe the unimaginable pain we are experiencing every moment of the day,” they said. “Losing our parents in such a horrific way is a devastation beyond comprehension. Beyond being our mom and dad, they were our dearest friends.”

Hollywood Tributes Pour In

Ryan’s co-star, Billy Crystal, joined in remembering Reiner through a message shared yesterday together with remarks by Larry David, Martin Short and Albert Brooks.

“His comedic touch was beyond compare, his love of getting the music of the dialogue just right, and his sharpening of the edge of a drama was simply elegant,” the tribute noted. “He cherished performers and improved scribes. His finest trait was granting creative liberty. He valued input and made you part of the team. They always felt they were working as a team. To be in his hands as a film-maker was a privilege but that is only part of his legacy.”

A Lasting Cinematic Legacy

When Harry Met Sally was a hit with both critics and audiences in 1989, grossing more than $93 million worldwide and securing Nora Ephron an Oscar nomination for best original screenplay.

Rob Reiner met Michele Singer Reiner while making When Harry Met Sally. The pair were brought together by Barry Sonnenfeld, a fellow filmmaker and pal.

Reiner’s celebrated filmography featured classics such as Misery, Stand by Me and The Princess Bride. The director and his wife were together in marriage for 36 years.